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In vitro results showed that HP55-coated capsules reduced insulin release at pH 1.2 from 90 to 10%

Expert Opin Pharmacother 2009;10:323-331

If you are using a liposomal format, this is less of a concern, but water remains the gold standard

Nonsteroidal antiinflammatory drug (NSAID) Aspirin Aspirin, a commonly used NSAID, primarily works by inhibiting cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, which in turn blocks thromboxane A 2 synthesis [124]